Transdermal delivery of topically applied compounds is limited by the stratum corneum (SC) protective barrier.\r\nPenetration enhancers have been employed to perturb the skin barrier and enhance the transdermal flux of drugs. The\r\nnovel excipient, dodecyl-2-N, N-dimethylaminopropionate hydrochloride (DDAIP-HCl), was evaluated for penetration\r\nactivity of minoxidil in human cadaver skin. Minoxidil skin flux through human cadaver skin mounted on Franz cells\r\nwas investigated with and without the presence of DDAIP-HCl. Enhanced minoxidil permeation levels were observed\r\nwith DDAIP-HCl at concentrations of 0.05% and 0.5% through human cadaver skin relative to the formulation of the\r\nmarketed hair loss product Rogaine�® (5% minoxidil) over a 24-hour period. Increased minoxidil penetration may lead\r\nto a better efficacy and clinical response in the treatment of male pattern hair loss or Androgenetic alope
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